Great Rivers & Routes

Three great rivers — the Mississippi, Missouri and Illinois — meet iconic Route 66 in Southwest Illinois. Take the scenic route through this region known for historical sites, river towns and outdoor adventures.

Epic road trips

Follow the Great River Road and Route 66 along bluffs, shores and river towns.

Midwest heritage

Discover ancient sites, early exploration routes and landmarks tied to U.S. history.

Outdoor excitement

Hike, bike and paddle through the region’s lush river valleys.

Southwest Illinois Signatures

Route 66 icons

  • Snack, shop and take photos with giant statues at this quirky Mother Road landmark.

  • Dine at one of Route 66’s longest-running restaurants, serving travelers since 1924.

  • Walk or bike across this Mississippi River bridge once used by Route 66 motorists.

Open-Air History

  • Scale what remains of an ancient city at this UNESCO World Heritage Site.

  • Stand at the junction of two great rivers and relive the start of a storied expedition.

  • Discover centuries of history and spectacular views in Illinois’ largest state park.

Experiences

Driving the Great River Road in Southwest Illinois

Meeting of the Great Rivers Scenic Byway

Experience a breathtaking drive where the Mississippi, Missouri and Illinois meet.

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Kids enjoying the exhibits at Lewis & Clark State Historic Site in Southwest Illinois

Kid-Approved Adventures

Spot wildlife, visit interpretive centers and enjoy retro fun on Route 66.

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River views from the Grafton SkyTour in Southwest Illinois

Blufftop Panoramas

Ride a gondola, zip line or coaster for sweeping views over the rivers.

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Posing with a Route 66 sign in Hamel, Illinois

Roadside Photo Ops

Check out murals and giant statues like the World’s Largest Catsup Bottle.

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Enjoying wine and river views at Tara Point in Grafton, Illinois

Local Flavors

Sip wine with river views or enjoy classic American diner fare on Route 66.

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Trip Ideas & Itineraries

Browse articles featuring the best of Southwest Illinois, from riverside drives to Route 66 landmarks and historical sites.

Nostalgia And New Experiences On And Around Route 66 In Illinois

Heritage-Rich Experiences Across the USA
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Charming Small Towns Along Route 66 in Illinois, Missouri and Kansas

Retro-Themed to Certified Green: 10 Unique Places to Stay on Route 66
Aerial view of the Great River Road in Southwest Illinois

Great Rivers & Routes of Southwest Illinois

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