Once used to transport goods across the USA, this historic highway now makes for one of the best vacation road trips in the world. From the major cities of Dallas, Oklahoma City, Amarillo and Santa Fe to all the little stops in between, you’re in for quite a ride.

It’s time to get moving! We’ve compiled a list of the top destinations that’ll get your body moving from sunup to sundown. Kayaking, hiking, fishing, mountain biking and more: It’s all available in these fitness-oriented destinations.

The sounds and history of the Mississippi River are alive: You just have to listen. Feel the music on an exploration of the riverside cities of Minnesota, Iowa and Missouri.

Test your physical limits and get to know this rugged region of the USA as you embark on an adventure through the wild landscapes and breathtaking rock formations of Utah and Arizona, with stops along the way to admire the bright colors of Nevada.

Join the adventure across Georgia, South Carolina, and North Carolina to develop a richer understanding of Black history, the Gullah people, and the southern way of life.

From the sweet sips of small-batch bourbon to the rolling pastures of horse country, you're guaranteed to get a true taste of the American spirit in Tennessee, Kentucky and Ohio.

Make memories that you'll cherish for generations to come, all at the Most Magical Place on Earth. Dream up your next vacation during the 50th anniversary celebration of Walt Disney World Resort in Florida

Follow along as three generations of women come together to relax, recharge and reconnect in the healing surroundings of Greater Palm Springs, California.

Famous for its scenic River Walk and the Alamo – one of the five UNESCO-recognized missions in the city – San Antonio has many lively neighborhoods ideal for strolling, shopping and dining.

Experience the authentic charm, compelling history and culture, and delectable culinary offerings of southeastern USA on this tour through Georgia, Alabama and Mississippi.

Tackle epic slopes in Nevada, California and Utah. Each ski resort is a little different, but all are known for their world-class powder, down-to-earth vibes and family-friendly appeal.

The Midwest is known for wide-open spaces, kind folks and farm towns, but dotted across the plains, you’ll find truly special cities and experiences in Missouri, Kansas, Iowa and Nebraska.

The soulful ballads of the blues changed music forever, and it all started in the Deep South. In Mississippi and Arkansas, tour historic sites and cultural icons in the cities where it all began.

Take off on a coastal excursion across Delaware, New Jersey and Rhode Island. You’ll wander lovable towns, pristine beaches and festive boardwalks lined with galleries, restaurants and more.

In Michigan, Illinois and Minnesota, get to know the USA’s Great Lakes region. See the world’s largest freshwater lakes, and roam historic cities, vibrant art scenes and foodie destinations.

Explore scenic beauty, vibrant food scenes and downtown gems across Pennsylvania and West Virginia on a vacation full of unique discoveries, mountain vistas and untouched wilderness.

Tour the lush valleys and rugged coastlines of Washington and Oregon, and sample world-class pinot noir, small-batch coffee and the fresh coastal cuisine that makes this region so special.

From iconic landscapes to city lights, California and Nevada offer an exciting slice of Americana to all who visit. Follow this road trip to enjoy colorful places, great food and rich culture.

Louisiana is known for New Orleans, the birthplace of jazz and the heart of Mardi Gras. Beyond New Orleans, explore tranquil bayous, tour plantations and dance to live music in friendly towns.

Rugged beauty is a hallmark of Wyoming, as seen at Yellowstone National Park, Grand Teton National Park and Devils Tower National Monument. You'll also find historic towns and an Old West vibe.

The U.S. Virgin Islands shines with practically endless sunny days – perfect for beach outings, outdoor adventure, touring cultural sites and sampling local cuisine.

The quaint Hudson River Valley is dotted with small towns and mountain views. Find spots to absorb idyllic scenery, shop boutiques and antiques, tour art galleries and savor refined cuisine.

Embrace outdoor fun in the western state of Colorado, whether skiing, rafting, hiking, climbing, soaking in a hot spring or dining al fresco at an award-winning restaurant.

The gateway to Alaska’s wild interior, Fairbanks has hot springs, snowy tundra, the midnight sun and northern lights. Get out into this gorgeous wilderness on a gold panning excursion.

On the northeastern side of Hawaii Island, Hilo is known for its waterfalls, rain forests and gardens. Beautiful beaches offer surfing and snorkeling, while local markets and eateries feature fresh fish and produce.

More than gorgeous beaches and epic nightlife, Miami is best explored through its neighborhoods. Tour Art Deco architecture, see colorful murals and don’t miss world-famous Art Basel.

You can enjoy four seasons of adventure, luxurious lodging and fine dining in Sugarbush, but Skiing is the local passion at this historic resort.

Travel through South Dakota, a state famed for Mount Rushmore National Memorial, Crazy Horse Memorial and Badlands National Park. Don’t forget to explore bustling Old West towns like Deadwood and Rapid City.

You can expect sunny days and breathtaking desert landscapes in Phoenix, but you might be surprised by its music scene, edgy bars and restaurants, and impressive museums.

Sedona’s iconic red rocks are ready for exploration, via foot, Jeep tour and mountain bike. Get immersed in the energy of this other-worldly escape.

In Memphis, tour Elvis Presley’s Graceland, visit the National Civil Rights Museum and see the ducks of The Peabody hotel. Save some time to see street art and savor authentic soul food.

Music is at the heart of Nashville, a thriving home for country, rock, bluegrass, Americana, blues and soul – but its creative spirit extends to its whiskey distilleries and dining scene.

Natural beauty is a hallmark of Puerto Rico, from El Yunque National Forest to beautiful beaches. Beyond the scenery of this Caribbean island, explore its colorful cities, starting in Old San Juan.

Quirky Austin, the capital of Texas, is known for its world-renowned festivals, legendary live music, urban outdoor adventures and stellar dining options – particularly its food trucks.

In the USA’s capital city, Washington, D.C., visit the National Mall’s monuments and museums, then dive into the artistic vibes and colorful cultures of local neighborhoods.

Asheville boasts the lavish Biltmore Estate, hundreds of art studios and galleries, and a stellar culinary and craft beer scene – all nestled against the awe-inspiring scenery of the Blue Ridge Mountains.

Sip bourbon at a distillery and travel the rolling hills and horse farms of Kentucky, known as The Bluegrass State.

In California, relish outdoor adventure in the mountains, relax in a seaside village, bike through wine country and learn to surf on a perfect stretch of beach.

In the heart of the midwestern USA, Ohio has vibrant cities and a warm rural heartland, all accented by welcoming local charm.

Home to five national parks, Utah beckons with its striking sandstone formations and red-rock mountains, playgrounds for outdoor adventure of all kinds.

In Maine, stroll the cobblestone streets of Portland’s Old Port, dine on a fresh lobster roll, visit historic lighthouses, take a boat tour and explore Acadia National Park.

Think snow-capped mountains, picturesque glaciers, crystalline rivers and verdant prairies. Montana boasts Glacier and Yellowstone national parks, as well as Western history and small-town charm.

New York City is often called the “city that never sleeps.” There’s so much to do here: iconic attractions, a hard-to-beat culinary scene and hidden gems around every corner.

Tour Massachusetts from big-city Boston to the natural wonders of the coast. Follow the Freedom Trail through Boston, then kick back in Cape Cod, Nantucket and Martha’s Vineyard.

Cape Canaveral’s claim to fame is Kennedy Space Center, but you'll find natural beauty here too at Atlantic Ocean beaches and wetlands, including Canaveral National Seashore.

Oklahoma has more kilometers of Route 66 than anywhere else. Travel it to find Western history, Native American culture and pure Americana amid endless plains, rugged mountains and lush forests.

In the shadow of the Sandia Mountains on the Rio Grande River, experience Abuquerque’s Old Town, ride the Sandia Peak Tramway or visit in October for the International Balloon Fiesta.